Crystalline form of a beta-lactamase inhibitor
AssigneeCubist Pharmaceuticals, Inc.
InventorsYou Seok Hwang, Jian-Qiao Gu, Akash Jain, Sudhakar Garad, Jacob P. Sizemore
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Abstract
This disclosure provides compositions containing solid forms of sodium (2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate, and methods of manufacturing and using these compositions.
Claims20
Hydrate 1 of sodium (2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate, wherein Hydrate 1 is characterized by an X-ray powder diffraction pattern having peaks expressed in degrees-2-theta at angles 13.1±0.2°, 14.3±0.2°, 20.5±0.2°, and 21.5±0.2°.
A pharmaceutical composition comprising the Hydrate 1 of sodium (2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate, and a pharmaceutically acceptable carrier, wherein Hydrate 1 is characterized by an X-ray powder diffraction pattern having peaks expressed in degrees-2-theta at angles 13.1±0.2°, 14.3±0.2°, 20.5±0.2°, and 21.5±0.2°.
A pharmaceutical composition comprising the Hydrate 1 of sodium (2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate and at least one β-lactam antibiotic, wherein Hydrate 1 is characterized by an X-ray powder diffraction pattern having peaks expressed in degrees-2-theta at angles 13.1±0.2°, 14.3±0.2°, 20.5±0.2°, and 21.5±0.2°.
Dependencies are inferred from the claim text.