Compounds and uses thereof for the modulation of hemoglobin

A compound of formula (I):

• or an N oxide thereof, or a pharmaceutically acceptable salt of each thereof, wherein
• A is selected from the group consisting of:
• wherein R1 is C1-C6 alkyl optionally substituted with 3-6 fluoro atoms;
• R2 is hydrogen or C1-C6 alkyl;
• R3 is C1-C6 alkyl;
• each R4 independently is hydrogen or C1-C6 alkyl;
• ring B is
• or ring B together with A is:
• X is oxygen, S, SO, or SO2;
• ring C is selected from the group consisting of:
• wherein R5 is selected from the group consisting of hydrogen;
• C1-C6 alkoxy, optionally substituted with a C1-C6 alkoxy group or with up to 3 fluoro atoms;
• C1-C6 alkyl;
• and halo;
• R6 is hydrogen or halo;
• R is hydrogen, a phosphate, a diphosphate, a phosphonate or a phosphoramidate containing moiety, or another promoiety;
• provided that the compound of formula (I) comprises at least 1 OR group where R is not hydrogen.