Sodium containing sol-gel derived bioactive glasses and uses thereof including hemostasis
AssigneeNovabone Products, LLC
InventorsGregory J. Pomrink, Jipin Zhong, Zehra Tosun, Roy Layne Howell, Cecilia Cao
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Abstract
A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof which include introducing Na2O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCl, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.
Claims31
A sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of NaCl and C2H5ONa.
A sol-gel bioactive glass comprising Si, Ca, P, and Na, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source selected from the group consisting of NaCl and C2H5ONa.
A method of making a sol-gel bioactive glass including Si, Ca, P, and Na comprising:
- mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of NaCl and C2H5ONa;
- aging the mixture, and
- drying the mixture to form the sol-gel bioactive glass.
A method of making a sol-gel bioactive glass including Si, Ca, P, and Na comprising:
- mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of NaCl and C2H5ONa, and
- drying the mixture at a temperature of 100° C. or lower.
A sol-gel bioactive glass comprising Si, an alkaline earth metal, P, and alkali metal, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source selected from the group consisting of organosodium containing compound or a metal salt other than sodium nitrate.
A sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is sodium silicate.
A method for achieving hemostasis in a patient in need of treatment thereof comprising contacting the patient with the sol-gel bioactive glass comprising Si, Ca, P, and Na, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source, wherein the sodium source is sodium silicate.
A method of making a sol-gel bioactive glass including Si, Ca, P, and Na comprising:
- mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is sodium silicate;
- aging the mixture, and
- drying the mixture to form the sol-gel bioactive glass.
A sol-gel bioactive glass precursor including a source of Si, Ca, and Na, wherein the sodium source is selected from the group consisting of NaCl and C2H5ONa.
Dependencies are inferred from the claim text.