Matrix compositions for controlled release of peptide and polypeptide molecules
AssigneePolypid Ltd.
InventorNoam Emanuel
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions for controlled release of a peptidic molecule comprising a lipid-saturated matrix comprising a biocompatible polymer and a peptidic molecule associated with PEG. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of the peptidic molecule.
Claims33
A matrix composition comprising:
- a. a biocompatible polymer in association with a first lipid component comprising cholesterol;
- b. a second lipid component comprising at least one phospholipid having fatty acid moieties of at least 14 carbons, said phospholipid being selected from the group consisting of (i) phosphatidylcholine or a derivative thereof, (ii) a mixture of phosphatidylcholines or derivatives thereof, (iii) a phosphatidylethanolamine or a derivative thereof, and any combination of (i), (ii) and (iii);
- and
- c. at least one peptidic molecule in association with polyethylene glycol (PEG);
- wherein the matrix composition is adapted for providing sustained and/or controlled release of the peptidic molecule, and wherein the weight ratio of the peptidic molecule and PEG is between 10:1 and 1:1 inclusive.
4-6. (canceled)
(canceled)
(canceled)
19-21. (canceled)
(canceled)
(canceled)
30-31. (canceled)
33-35. (canceled)
(canceled)
A method of producing a matrix composition for delivery and sustained and/or controlled release of a peptidic molecule comprising the steps of:
- a. mixing into a first solvent (i) a biocompatible polymer and (ii) a first lipid component comprising cholesterol;
- wherein said first solvent is a volatile organic solvent;
- b. mixing the peptidic molecule into a second solvent to form a solution and adding polyethylene glycol into the solution;
- c. mixing the solution obtained in step (b) with a second lipid component comprising at least one phospholipid having fatty acid moieties of at least 14 carbons, said phospholipid being selected from the group consisting of (i) phosphatidylcholine or a derivative thereof, (ii) a mixture of phosphatidylcholines or derivatives thereof, (iii) a phosphatidylethanolamine or a derivative thereof, and any combination of (i), (ii) and (iii);
- d. mixing the solutions obtained in steps (a) and (c) to form a homogeneous mixture;
- and
- e. removing the solvents by heating to no more than 60° C.;
- thereby producing a homogeneous polymer-phospholipids matrix comprising the peptidic molecule.
40-51. (canceled)
Dependencies are inferred from the claim text.