Acid Stable Liposomal Compositions And Methods For Producing The Same
AssigneeThe Penn State Research Foundation
InventorsMark Kester, Karam El-Bayoumy, Christine Skibinski, Arunangshu Das
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Abstract
The present invention relates to a liposomal formulation for oral delivery of a bioactive agent that considers pH stability and oxidative stability of a bioactive ingredient. These lipid formulations are superior to conventional liposomes due to their stability, thereby circumventing the need for intra-venous delivery of bioactive agents. In one embodiment, the methods and compositions of the present invention relate to the oral delivery of insulin or a prodrug thereof.
Claims31
A composition for encapsulating a biological agent, comprising at least one lipid, wherein the at least one lipid comprises a polyol backbone formulated for oral administration and delivery of the bioactive agent.
A method of producing a carrier complex comprising:
- drying a lipid solution having one or more archaeo-type lipid molecules under a nitrogen atmosphere wherein the lipid solution further comprises at least one bioactive agent in a therapeutically effective amount;
- rehydrating the lipid solution;
- heating the solution to at least about 50° C.;
- sonicating the rehydrated lipid solution;
- performing a sizing step;
- and removing excess bioactive agent.
A liposomal formulation comprising 1,2-di-O-hexadecyl-sn-glycero-3-phosphatidylcholine and 1,2-di-O-phytanyl-sn-glycero-3-phosphatidylethanolamine.
Dependencies are inferred from the claim text.