Nanofibrous materials as drug, protein, or genetic release vehicles

A fabricated textile suitable for use as a medical article, the fabricated textile being formed by an electrospinning perfusion method comprising steps of:

• dissolving a non-biodegradable polymer, and a biologically-active agent in a solvent to provide an admixture, the dissolving step occurring at an ice-cold temperature;
• permitting the admixture to warm to a temperature between about 20° C. and about 50° C.;
• loading the admixture into an electrospinning perfusion instrument which can be set at a specified flow rate;
• perfusing the admixture onto a target surface at the specified flow rate, the step of perfusing occurring at a temperature between about 20° C. and about 50° C. to provide a perfused material;
• and
• permitting trace solvent to be removed from the perfused material to form a fabricated textile.

A method of using a fabricated textile, the method comprising steps of:

• placing a fabricated textile contiguous with biological tissue, the fabricated textile being formed by an electrospinning perfusion method comprising steps of:
• dissolving a non-biodegradable polymer, and a biologically-active agent in a solvent to provide an admixture, the dissolving step occurring at an ice-cold temperature;
• permitting the admixture to warm to a temperature between about 20° C. and about 50° C.;
• loading the admixture into an electrospinning perfusion instrument which can be set at a specified flow rate;
• perfusing the admixture onto a target surface at the specified flow rate, the step of perfusing occurring at a temperature between about 20° C. and about 50° C. to provide a perfused material;
• and
• permitting trace solvent to be removed from the perfused material to form the fabricated textile;
• wherein the biologically active agent is released over a period of time from the fabricated textile after the fabricated textile is placed contiguous with the biological tissue.