Intra-testicular Injection of Immunogens
AssigneeArk Sciences, Inc.
InventorMin Wang
Life of this patent
Estimating the term…
Abstract
A method for inducing an immune response by injecting an immunogen into a subject's testis. A composition for intra-testicular injection including an immunogen such as a rabies vaccine and a chemical sterilant formed of zinc gluconate and an amino acid capable of forming an aqueous solution neutralized to a pH from 6.0 to 7.5. When injected intra-testicularly, the immunogen is slowly released reducing or eliminating the need for a “booster” dose, while the chemical sterilant is effective at reducing the dog population.
Claims12
A method for inducing an immune response comprising
- forming a solution of an immunogen capable of inducing an immune response when injected intramuscularly into a subject's body, said solution having a pH between about 6.0 and 7.5;
- and,
- injecting said solution into each testis of a subject.
A composition for intra-testicular injection comprising a chemical sterilant and an immunogen capable of inducing an immune response, said chemical sterilant comprising zinc gluconate and an amino acid capable of forming an aqueous solution, said zinc gluconate and amino acid being present in substantially equal molar amounts and at a concentration in the range from about 0.05 M to 2.0 M and neutralized to a pH from about 6.0 to about 7.5.
A method for forming a composition for intra-testicular injection for dog population and rabies control comprising
- preparing a chemical sterilant comprising zinc gluconate and an amino acid capable of forming an aqueous solution, said zinc gluconate and amino acid being present in substantially equal molar amounts and at a concentration in the range from about 0.05 M to 2.0 M and neutralized to a pH between about 6.0 and about 7.5;
- reconstituting a dried inactivated rabies vaccine;
- combining the chemical sterilant and reconstituted inactivated rabies vaccine for intra-testicular injection immediately after the inactivated rabies vaccine has been reconstituted or refrigerating the combination of chemical sterilant and reconstituted inactivated rabies vaccine for later injection.
A method for administering a chemical sterilant and a rabies vaccine to male dogs for population and rabies control, said method comprising,
- preparing a chemical sterilant comprising zinc gluconate and an amino acid capable of forming an aqueous solution, said zinc gluconate and amino acid being present in substantially equal molar amounts and at a concentration in the range from about 0.05 M to 1.0 M and neutralized to a pH between about 6.0 and about 7.5;
- reconstituting a dried inactivated rabies vaccine;
- combining the chemical sterilant and reconstituted inactivated rabies vaccine;
- injecting the combination of chemical sterilant and inactivated rabies vaccine into the dog's testes, said chemical sterilant present in an amount sufficient to render the dog sterile and the inactivated rabies vaccine present in an amount sufficient to inoculate the dog against rabies.
Dependencies are inferred from the claim text.