Heat-Stable Respiratory Syncytial Virus F Protein Oligomers and Their Use in Immunological Compositions

A heat-stable oligomeric recombinant polypeptide presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus F protein, said polypeptide comprising

• the Respiratory Syncytial Virus F protein ectodomain,
• from which the HRB region is functionally deleted, and
• from which the transmembrane and cytoplasmic domains are deleted and replaced with a heterologous trimerization domain,
• and
• wherein the two multibasic furin cleavage sites in said Respiratory Syncytial Virus F protein ectodomain are deleted or mutated, thereby rendering said furin cleavage sites defective.