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US 2014/0271688 A1Published application
Antibody drug conjugates
AssigneesIrm LLC, Novartis AG
InventorsTinya Abrams, Steven Bruce Cohen, Christie P. Fanton, Thomas Huber, Kathy Miller, Siew Ho Schleyer, Kathrin Ulrike Tissot-Daguette, Catrin Finner
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Abstract
The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
Claims53
An antibody drug conjugate of the formula
- Ab-(L-(D)n)n
- or a pharmaceutically acceptable salt thereof;
- wherein
- Ab is an antibody or antigen binding fragment thereof that specifically binds to an epitope of human cKIT;
- L is a linker;
- D is a drug moiety;
- m is an integer from 1 to 8;
- and
- n is an integer from 1 to 10.
6 more elements
An antibody drug conjugate of the formula
- or a pharmaceutically acceptable salt thereof;
- wherein
- Ab is an antibody or antigen binding fragment thereof that specifically binds to human cKIT, and comprises at least n number of primary amines;
- and
- n is an integer from 1 to 10.
2 more elements
(canceled)
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Dependencies are inferred from the claim text.