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AssigneeThe Wistar Institute of Anatomy and Biology
InventorsDario C. Altieri, Young Chan Chae
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A method for inhibiting tumor cell migration or metastasis of a cancer in a mammalian subject comprises one or more of the steps of administering to a subject a therapeutically effective amount of a composition comprising a molecule that: suppresses focal adhesion kinase (FAK) activity or phosphorylation; suppresses ULK1 kinase activity; suppresses activation or signaling of the mTORC1 (Ser757) pathway; activates AMPK; activates FIP200; or activates LKB1, in a cancer cell. Still another method of inhibiting tumor cell migration involves inhibiting phosphorylation of ULK1 on Ser757 in subjects with lung cancer. Suppressing activation or signaling of the mTORC1 (Ser757) pathway in subjects is in one aspect useful in treating lung cancer.
A method for inhibiting tumor cell migration in a mammalian subject comprising:
A therapeutic composition for inhibiting tumor migration in a mammalian subject comprising one or more of Gamitrinib, an antibody to FAK, an antibody to ULK1, an antibody to mTORC1, an antibody to TRAP1, or a nucleic acid molecule that expresses in a host cell a target selected from AMPK, FIP200 or LKB1
A therapeutic composition for inhibiting tumor migration in a mammalian subject comprising one or more of a nucleic acid molecule that bind to a target selected from FAK, ULK1, mTORC1, TRAP1, AMPK, FIP200 or LKB1.
Dependencies are inferred from the claim text.