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AssigneeBayer HealthCare LLC
InventorsYE JIN, John E. Murphy, Terry Hermiston, Timothy Myler, Frank Dittmer, Michael Strerath, Uwe Gritzan
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This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.
A monoclonal antibody capable of binding the antithrombin (β) heparin complex (ATβH), wherein the heavy chain of said antibody comprises:
A monoclonal antibody capable of binding ATβH, wherein the heavy chain of said antibody comprises:
A monoclonal antibody capable of binding ATβH, wherein the heavy chain of said antibody comprises:
A monoclonal antibody capable of binding ATβH, wherein the heavy chain of said antibody comprises:
A monoclonal antibody capable of binding ATβH, wherein the heavy chain of said antibody comprises:
An isolated monoclonal antibody that binds to ATβH and inhibits anticoagulant activity, wherein said antibody comprises a heavy chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
An isolated monoclonal antibody that binds to AtβH and inhibits anticoagulant activity, wherein said antibody further comprises a light chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
An isolated monoclonal antibody that binds to ATβH and inhibits anticoagulant activity, wherein said antibody comprises a CDR3 comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
An isolated monoclonal antibody that binds to ATβH and inhibits anticoagulant activity, wherein said antibody comprises a CDR3 comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
An isolated monoclonal antibody that binds to the active site of ATβH.
An isolated monoclonal antibody that binds to ATβH and provides anticoagulant activity, wherein the isolated monoclonal antibody exhibits minimal binding to AT and wherein said antibody is a fully human antibody.
An isolated monoclonal antibody that binds to human ATβH.
An isolated nucleic acid molecule encoding an antibody that binds to ATβH and inhibits anticoagulant activity, wherein the antibody comprises a light chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
An isolated nucleic acid molecule encoding an antibody that binds to ATβH and inhibits anticoagulant activity, wherein the antibody comprises a heavy chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
Dependencies are inferred from the claim text.