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AssigneeAdvanced Cell Technology, Inc.
InventorsQiang Feng, Shi-Jiang Lu, Robert P. Lanza
Estimating the term…
Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
A pharmaceutical preparation that is suitable for use in a human patient comprising at least 108 platelets, wherein the preparation is substantially free of leukocytes and wherein substantially all of the platelets are functional.
A bioreactor having weakly adherent or non-adherent megakaryocytes that produce functional platelets without feeder cells.
A composition comprising at least 109 megakaryocyte lineage specific progenitors (MLPs).
A method for producing platelets from megakaryocytes comprising the steps of:
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19-27. (canceled)
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40-41. (canceled)
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Dependencies are inferred from the claim text.