Renal stem cells isolated from kidney
AssigneeUniversity of Miami
InventorsJoshua M. Hare, Samirah Gomes, Erika B. Rangel
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Abstract
A novel renal precursor cell is identified from kidney tissue. The cell is multipotent capable of forming renal epithelial and endothelial tissues. The cell can be amplified in culture and maintains stemness over multiple passages. This cell fulfills a major unmet need as a cell-based source for kidney regeneration or repair. Treatment of kidney diseases and disorders (e.g., glomerularpathies and acute tubular necrosis) may be improved thereby.
Claims20
An in vitro process of producing a renal stem cell, the process comprising:
- (a) isolating c-Kit+/Lin− cells derived from kidney tissue and
- (b) expanding the c-Kit+/Lin− cells by in vitro cell culture to produce the renal stem cell.
An isolated renal stem cell, which is c-Kit+/Lin− and derived from kidney tissue.
Dependencies are inferred from the claim text.