Antibodies that bind integrin alpha-v beta-8
AssigneeThe Regents of the University of California
InventorsStephen Nishimura, Jianlong Lou, Jody Lynn Baron, James Marks
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Abstract
Provided herein are antibodies with high affinity for the β8 subunit of αβ8.
Claims28
An isolated antibody that specifically binds αβ8,
- wherein the isolated antibody inhibits release of active, mature TGFβ peptide, but does not significantly inhibit adhesion of latent TGFβ to αβ8 on a αβ8-expressing cell;
- and
- wherein the isolated antibody binds formalin-fixed αβ8-expressing cells.
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An isolated antibody that specifically binds to αβ8, wherein said antibody does not inhibit release of active, mature TGFβ peptide or adhesion of latent TGFβ to αβ8 on a αβ8-expressing cell.
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The method of claim 34, wherein the contacting is in vivo.
The method of claim 34, wherein the contacting is in vitro.
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Dependencies are inferred from the claim text.