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US 2014/0271458 A1Published application
DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17
AssigneeAbbVie Inc.
InventorsTariq Ghayur, JiJie Gu, Maria Harris, Carrie Goodreau, Sonal Saluja
Life of this patent
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Abstract
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
Claims55
1-34. (canceled)
A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C—X2, wherein
- VD1 is a first variable domain;
- VD2 is a second variable domain;
- C is a constant domain;
- X1 is a linker;
- X2 is an Fc region that is either present or absent;
- and
- n is 0 or 1;
- wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding IL-1β and IL-17, wherein
- (i) the variable domains that form a functional target binding site for IL-1β comprise a sequence selected from the group consisting of SEQ ID NOs:
- 32-41;
- and
- (ii) the variable domains that form a functional target binding site for IL-17 comprise a sequence selected from the group consisting of SEQ ID NO:
- 44-47.
10 more elements
A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C—X2, wherein
- VD1 is a first variable domain;
- VD2 is a second variable domain;
- C is a constant domain;
- X1 is a linker,
- X2 is an Fc region that is either present or absent;
- n is 0 or 1,
- wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding IL-1β and IL-17, wherein
- (i) the variable domains that form a functional target binding site for IL-1β comprise:
- CDRs 1-3 from SEQ ID NO:
- 32 and CDRs 1-3 from SEQ ID NO:
- 33,
- CDRs 1-3 from SEQ ID NO:
- 34 and CDRs 1-3 from SEQ ID NO:
- 35,
- CDRs 1-3 from SEQ ID NO:
- 36 and CDRs 1-3 from SEQ ID NO:
- 37,
- CDRs 1-3 from SEQ ID NO:
- 38 and CDRs 1-3 from SEQ ID NO:
- 39, or
- CDRs 1-3 from SEQ ID NO:
- 40 and CDRs 1-3 from SEQ ID NO:
- 41;
- and
- (ii) the variable domains that form a functional target binding site for IL-17 comprise
- CDRs 1-3 from SEQ ID NO:
- 44 and CDRs 1-3 from SEQ ID NO:
- 45, or
- CDRs 1-3 from SEQ ID NO:
- 46 and CDRs 1-3 from SEQ ID NO:
- 47.
28 more elements
A binding protein capable of binding IL-1β and IL-17, wherein the binding protein comprises any one of:
- DVD2423 (comprising SEQ ID NOs:
- 48 and 49);
- DVD2424 (comprising SEQ ID NOs:
- 50 and 51);
- DVD2425 (comprising SEQ ID NOs:
- 52 and 53);
- DVD2426 (comprising SEQ ID NOs:
- 54 and 55);
- DVD2427 (comprising SEQ ID NOs:
- 56 and 57);
- DVD2428 (comprising SEQ ID NOs:
- 58 and 59);
- DVD2429 (comprising SEQ ID NOs:
- 60 and 61);
- DVD2430 (comprising SEQ ID NOs:
- 62 and 63);
- DVD2431 (comprising SEQ ID NOs:
- 64 and 65);
- DVD2432 (comprising SEQ ID NOs:
- 66 and 67);
- DVD2433 (comprising SEQ ID NOs:
- 68 and 69);
- DVD2434 (comprising SEQ ID NOs:
- 70 and 71);
- DVD2435 (comprising SEQ ID NOs:
- 72 and 73);
- DVD2436 (comprising SEQ ID NOs:
- 74 and 75);
- DVD2437 (comprising SEQ ID NOs:
- 76 and 77);
- DVD2438 (comprising SEQ ID NOs:
- 78 and 79);
- DVD2439 (comprising SEQ ID NOs:
- 80 and 81);
- DVD2440 (comprising SEQ ID NOs:
- 82 and 83);
- DVD2441 (comprising SEQ ID NOs:
- 84 and 85);
- DVD2442 (comprising SEQ ID NOs:
- 86 and 87);
- DVD3410 (comprising SEQ ID NOs:
- 88 and 89);
- DVD3411 (comprising SEQ ID NOs:
- 90 and 91);
- DVD3412 (comprising SEQ ID NOs:
- 92 and 93);
- DVD3413 (comprising SEQ ID NOs:
- 94 and 95);
- DVD3414 (comprising SEQ ID NOs:
- 96 and 97);
- DVD3415 (comprising SEQ ID NOs:
- 98 and 99);
- DVD3416 (comprising SEQ ID NOs:
- 100 and 101);
- DVD3417 (comprising SEQ ID NOs:
- 102 and 103);
- DVD3418 (comprising SEQ ID NOs:
- 104 and 105);
- DVD3419 (comprising SEQ ID NOs:
- 106 and 107);
- DVD3420 (comprising SEQ ID NOs:
- 108 and 109);
- DVD3421 (comprising SEQ ID NOs:
- 110 and 111);
- DVD3422 (comprising SEQ ID NOs:
- 112 and 113);
- DVD3423 (comprising SEQ ID NOs:
- 114 and 115);
- DVD3424 (comprising SEQ ID NOs:
- 116 and 117);
- and
- DVD3425 (comprising SEQ ID NOs:
- 118 and 119).
70 more elements
Dependencies are inferred from the claim text.