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US 2014/0235870 A1Published application
Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
AssigneeApicore, LLC
InventorsRavishanker Kovi, KeshavRao Rapole, Ashish Naik, Jayaraman Kannapan, Muralikrishna Madala, Sanjay Thakor
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Abstract
Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
Claims3
A method for making
- comprising the steps of
- treating adamantane 1-carboxylic acid with dimethyl sulfide and potassium carbonate to obtain
- treating the resulting compound with a reducing agent to obtain
- and
- treating the resulting compound with triethylamine, dichloromethane, and oxalylchloride.
2 more elements
A method for making
- comprising the steps of
- combining adamantane 1-carboxaldehyde with (S)-(+)-p-toluenesulfinamide using NaCN, NaHSO3 and potassium permanganate to obtain
- treating the resulting compound with acid to obtain
- and
- treating the resulting compound with dimethylformamide, potassium carbonate and phthalic anhydride.
2 more elements
Dependencies are inferred from the claim text.