N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives

A compound of formula (II)

• or a pharmaceutically acceptable salt, hydrate, or solvate thereof wherein:
• L is a bond, —SO2— or —O—;
• Y is W, alkyl or aryl, wherein said alkyl and aryl are unsubstituted or substituted with one or more substituents independently selected from W;
• W is halo, —OH, —CN, —NO2, —COR1, —COOR1, —CONR1R2, —CH(C(O)R1)2, —SO2R1 or —COX, wherein X is halo, and R1 and R2 are independently alkyl or aryl, or R1 and R2 are taken together to form a cycloalkyl or heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl are unsubstituted or substituted with one or more substituents;
• R is hydrogen, alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy, benzyloxy or —NR3R4, wherein said alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy and benzyloxy are unsubstituted or substituted with one or more substituents;
• and
• R3 and R4 are independently alkyl or aryl;
• provided that when Y is W and W is —OH, then L is a bond.

a compound of formula (Ia)

• or a pharmaceutically acceptable salt, hydrate, or solvate thereof wherein:
• L is a bond, —SO2— or —O—;
• Y is a heteroaryl, wherein said heteroaryl is unsubstituted or substituted with one or more substituents independently selected from W;
• W is halo, —OH, —CN, —NO2, —COR1, —COOR1, —CONR1R2, —CH(C(O)R1)2, —SO2R1, or —COX, wherein X is halo, and R1 and R2 are independently alkyl or aryl, or R1 and R2 are taken together to form a cycloalkyl or heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl are unsubstituted or substituted with one or more substituents;
• R is hydrogen, alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy, benzyloxy or —NR3R4, wherein said alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy, and benzyloxy are unsubstituted or substituted with one or more substituents;
• and
• R3 and R4 are independently alkyl or aryl.

a compound of formula (IIa)

• or a pharmaceutically acceptable salt, hydrate, or solvate thereof wherein:
• L is a bond, —SO2— or —O—;
• Y is a heteroaryl, wherein said heteroaryl is unsubstituted or substituted with one or more substituents independently selected from W;
• W is halo, —OH, —CN, —NO2, —COR1, —COOR1, —CONR1R2, —CH(C(O)R1)2, —SO2R1 or —COX, wherein X is halo, and R1 and R2 are independently alkyl or aryl, or R1 and R2 are taken together to form a cycloalkyl or heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl are unsubstituted or substituted with one or more substituents;
• R is hydrogen, alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy, benzyloxy or —NR3R4, wherein said alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy and benzyloxy are unsubstituted or substituted with one or more substituents;
• and
• R3 and R4 are independently alkyl or aryl.