Compositions and methods for the treatment of proliferative diseases
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsGerburg Wulf, Lewis C. Cantley
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Abstract
The present invention relates to pharmaceutical compositions that contain PI3K inhibitors (e.g., PBKa-specific inhibitors) and PARP inhibitors. The invention also provides methods for the treatment of proliferative diseases such as cancer (e.g., breast cancer) by administering the composition(s) to a subject.
Claims28
1-60. (canceled)
A composition comprising a therapeutically effective amount of at least one phosphatidyl inositol 3 kinase (PI3K) inhibitor and at least one poly(ADP-ribose) polymerase (PARP) inhibitor.
A method of treating a subject having a proliferative disease comprising the step of administering to the subject a therapeutically effective amount of at least one PI3K inhibitor and at least one PARP inhibitor in an amount sufficient to treat the subject.
Dependencies are inferred from the claim text.