Monocyclic pyridine derivative
AssigneeEisai R&D Management Co., Ltd.
InventorsSetsuo Funasaka, Toshimi Okada, Keigo Tanaka, Satoshi Nagao, Isao Ohashi, Yoshinobu Yamane, Yusuke Nakatani, Yuki Karoji
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AssigneeEisai R&D Management Co., Ltd.
InventorsSetsuo Funasaka, Toshimi Okada, Keigo Tanaka, Satoshi Nagao, Isao Ohashi, Yoshinobu Yamane, Yusuke Nakatani, Yuki Karoji
Estimating the term…
The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein n represents 0 to 2; A represents an arylene group or a heteroarylene group; G represents a single bond, an oxygen atom or —CH2—; E represents a nitrogen-containing non-aromatic heterocycle; R1 represents an alkoxy group or the like; R2 represents a hydrogen atom or the like; and R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom.
A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof:
(canceled)
5-((2-(4-(1-Ethylpiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide represented by the following structural formula, or a pharmaceutically acceptable salt thereof:
6-(2-Methoxyethoxy)-N-methyl-5-((2-(4-(1-methylpiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-1H-indole-1-carboxamide represented by the following structural formula, or a pharmaceutically acceptable salt thereof:
5-((2-(4-(1-(2-Hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide represented by the following structural formula, or a pharmaceutically acceptable salt thereof:
(canceled)
20-24. (canceled)
Dependencies are inferred from the claim text.