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US 2014/0235588 A1Published application
Substituted 1h-pyrazol-1,2,4-oxadiazole derivatives as sphingosine receptor modulators
AssigneeAllergan, Inc.
InventorsJanet A. Takeuchi, Ling Li, Wha Bin Im, KEN CHOW
Life of this patent
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Abstract
The present invention relates to substituted 1H-pyrazol-1,2,4-oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Claims9
A compound represented by Formula II, its enantiomers, diastereoisomers, tautomers, or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R2 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R3 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R4 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R5 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R6 is H or optionally substituted C1-6 alkyl;
- R7 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15,
- R8 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R9 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R10 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R11 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R12, NR13R14 or OR15;
- R12 is H, OH or optionally substituted C1-6 alkyl;
- R13 is H or optionally substituted C1-6 alkyl;
- R14 is H or optionally substituted C1-6 alkyl;
- R15 is H or optionally substituted C1-6 alkyl;
- W is PO3H2 or COOH;
- and
- a is 0 or 1.
16 more elements
Dependencies are inferred from the claim text.