Immunogenic escherichia coli heat stable enterotoxin
AssigneeBoard of Trustees of Michigan State University
InventorA. Mahdi Saeed
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Abstract
The present invention relates to methods and compositions for the treatment and prevention of diarrhea and diarrheal related diseases and disorders in both animals and humans. In some embodiments, the invention relates to the treatment of said diarrhea and diarrheal related diseases and disorders with a vaccine. In still further embodiments, the invention relates to the treatment of constipation using the disclosed methods and compositions.
Claims18
(canceled)
A conjugate that comprises a heat-stable enterotoxin (STa) protein from Escherichia coli having an amino terminus that is covalently attached to a carrier protein via a succinylated group selected from the group consisting of a succinylated carrier protein lysine group, and a succinylated carrier protein N-terminal amino group.
A method comprising administering to a mammal a conjugate that comprises a heat-stable enterotoxin (STa) protein from Escherichia coli having an amino terminus that is covalently attached to a carrier protein via a succinylated group selected from the group consisting of succinylated carrier protein lysine group, and a succinylated carrier protein N-terminal amino group.
Dependencies are inferred from the claim text.