Silica spheres and affinity carrier

Abstract

To provide an affinity carrier with a low pressure loss and a large binding capacity even when the linear flow rate of a solution to be made to pass therethrough is high. Silica spheres, which satisfy the following conditions: (a) the average particle size is from 30 μm to 40 μm as measured by a laser light scattering method; (b) the ratio (D10/D90) of the particle size (D10) of smaller 10% cumulative volume to the particle size (D90) of 90% cumulative volume in a particle size distribution as measured by a Coulter counter method, is at most 1.50; and (c) the average pore size is from 85 nm to 115 nm and the pore volume is at least 1.5 mL/g, as measured by a mercury intrusion technique.

Dependencies are inferred from the claim text.