Plaster having adjustable occlusion
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsWalter Müller, Patrick Mohr
Life of this patent
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Abstract
Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers.
Claims27
A transdermal or topical active ingredient patch having a nonocclusive backing layer which consists of a textile material, a matrix formed from one Or more polymer layers, with at least one active pharmaceutical ingredient in one or more of the layers, wherein the structure-forming base polymers of the layer or layers of the matrix layer which makes contact with the skin on application are nonocclusive or minimally occlusive and are pressure-sensitive adhesives and in at least one of the polymer layers there is a second polymer dispersed, which is immiscible or very minimally miscible with the base polymer and has a low water vapor permeability, which is polyisobutylene, a styrene-isoprene-styrene block polymer or a styrene-butadiene-styrene block polymer, the fraction of dispersed particles of the second polymer being between 7 and 40 wt %.
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Dependencies are inferred from the claim text.