US 2014/0234369 A1Published application

Live-attenuated compositions for bacterial infections

AssigneeNorthwestern University

InventorsDavid Klumpp, Anthony Schaeffer, Benjamin Billips

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Abstract

The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.

Claims7

Dependent claims

A composition comprising a live attenuated bacterial strain with a non-functional or deleted waal gene such that said live attenuated bacterial strain is lacking O-antigen ligase function.

Dependencies are inferred from the claim text.

Facts

Application: 14/263,276Filed 28 Apr 2014
Priority: 14 May 2009
Published: 21 Aug 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 39/0258
Enterobacteriales, e.g. Enterobacter: escherichia
A61K 35/74
Microorganisms or materials therefrom: bacteria
A61K 35/744
Probiotics: lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61P 13/00
Drugs for disorders of the urinary system

Family

Application61/178,384Us provisional application · filed 14 May 2009
Application13/266,346Continuation · filed 23 Dec 2011
Application14/263,276Continuation
US 2012/0093869 A1Published application
US 8,709,444 B2Related patent
US 9,248,175 B2Related patent
US 2014/0234369 A1This patent

From the US filing history. Foreign family members aren’t listed.

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