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AssigneeInnate Pharma
InventorsKARINE CHEMIN, LAURENT GAUTHIER, YANNIS MOREL, CARINE PATUREL, AGNES TISSERANT
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The present invention relates to antibodies, antibody fragments, and derivatives thereof that specifically bind to TLR3 cell receptors present on the surface of cells. The invention also relates to hybridomas producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to detect TLR3 levels on the surface of cells, and the use of such antibodies and compositions for diagnostic or therapeutic purposes in subjects.
A method of producing an antibody that specifically binds a TLR3 polypeptide in paraffin-embedded tissue sections, said method comprising the steps of:
A method of constituting a group of patients or samples therefrom, said method comprising selecting a group of patients or samples consisting where each patient or sample in the group has tumor cells which are bound by an antibody that specifically binds a human toll like receptor 3, (TLR3)polypeptide, wherein said antibody comprises the light chain variable region sequence of SEQ ID NO:3 and the heavy chain variable region sequence of SEQ ID NO:4, and wherein said antibody is designated as 40F9.
Dependencies are inferred from the claim text.