Modulators of 4-1bb and immune responses
AssigneeLa Jolla Institute for Allergy and Immunology
InventorsMichael Croft, Shravan Madireddi
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Abstract
The invention provides peptides and fragments, methods and uses based upon modulating the binding or interaction between 4-1BB and galectins such as Galectin-9. Modulating such binding or interaction between 4-1BB and a galectin, such as Galectin 9. modulates an immune response.
Claims24
A method of modulating an immune response, comprising contacting 4-1BB or a galectin with an agent that modulates binding of 4-1BB to the galectin, thereby modulating an immune response.
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A method of modulating an immune response in a subject, comprising administering an agent that modulates binding of 4-1BB to a galectin to the subject, thereby modulating the immune response in the subject.
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Dependencies are inferred from the claim text.