Method of treatment using nanoparticulate compositions having lysozyme as a surface stabilizer
AssigneeAlkermes Pharma Ireland Limited
InventorsChristian F. Wertz, Niels P. Ryde
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Abstract
The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.
Claims32
A bioadhesive nanoparticulate composition comprising at least one active agent having lysozyme adsorbed on the surface thereof as a surface stabilizer in an amount sufficient to maintain the active agent particles at an effective average particle size of less than about 2000 nm.
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A method of making a bioadhesive, nanoparticulate composition comprising at least one active agent having lysozyme adsorbed on the surface thereof in an amount sufficient to maintain the active agent particles at an effective average particle size of less than about 2000 nm,
- said method comprising contacting said at least one active agent with lysozyme for a time and under conditions sufficient to provide an active agent/lysozyme composition having an effective average particle size of less than about 2000 nm.
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A method of treating a mammal in need with a bioadhesive nanoparticulate composition comprising:
- (a) at least one active agent;
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- (b) lysozyme as a surface stabilizer adsorbed on the surface of the active agent,
- wherein the method comprises administering to said mammal a therapeutically effective amount of the nanoparticulate composition, wherein the active agent particles have an effective average particle size of less than about 2000 nm.
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Dependencies are inferred from the claim text.