Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders

A metal-bisphosphonate nanoparticle comprising:

• (a) a core comprising a multivalent metal ion-bisphosphonate complex;
• and
• (b) a coating layer surrounding at least a portion of an outer surface of the core, wherein the coating layer comprises a metal oxide, a polymer, a single lipid layer, a lipid bilayer, an organic polymer, or a targeting moiety.

49-50. (canceled)

A metal-bisphosphonate nanoparticle comprising a core comprising:

• (a) M1, wherein M1 is a multivalent metal ion;
• and
• (b) a bisphosphonate, wherein the bisphosphonate comprises a metal complex having the formula M2Lx, wherein x is an integer of 2 or greater, M2 is a second metal ion, each L is a metal ion ligand, and wherein at least two L comprise a phosphonate group.

(canceled)