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US 2014/0230081 A1Published application
Polynucleotide, polypeptide, animal model and method for the development of complement system modulators
AssigneeBayer Intellectual Property GmbH
InventorsStefan Golz, Andreas Geerts, Maria Köllnberger
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Abstract
The present invention is in the field of molecular biology, more particularly, the present invention relates to nucleic acid sequences and amino acid sequences of a hamster C5aR1 and the use of hamster as an animal model for the characterization of complement system modulators within drug discovery.
Claims17
A C5aR1 polynucleotide, selected from a group consisting of
- (i) nucleic acid molecules encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2,
- (ii) nucleic acid molecules comprising the sequence of SEQ ID NO:
- 1,
- (iii) nucleic acid molecules having the sequence of SEQ ID NO:
- 1,
- (iv) nucleic acid molecules the complementary strand of which hybridizes under stringent conditions to a nucleic acid molecule of (i), (ii), or (iii);
- and
- (v) nucleic acid molecules the sequence of which differs from the sequence of a nucleic acid molecule of (iii) due to the degeneracy of the genetic code;
- wherein the polypeptide encoded by said nucleic acid molecule has C5aR1 activity.
7 more elements
A C5aR polypeptide selected from a group consisting of
- (i) polypeptides having the sequence of SEQ ID NO:
- 2,
- (ii) polypeptides comprising the sequence of SEQ ID NO:
- 2,
- (iii) polypeptides encoded by C5aR1 polynucleotides as disclosed above;
- and
- (iv) polypeptides which have at least 85%, 90%, 95%, 98% or 99% identity,
- wherein said polypeptide has C5aR1 activity.
5 more elements
Dependencies are inferred from the claim text.