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US 2014/0228590 A1Published application
Simplified radiosynthesis of [18f]fluoromethyl bromide
AssigneePiramal Imaging SA
InventorKeith Graham
Life of this patent
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Abstract
This invention relates to an improved radiosynthesis of [18F]fluoromethyl bromide, whereby the distillation step has been improved to remove higher amounts of the dibromomethane radiolabeling precursor.
Claims14
A method for the purification of compounds of formula (I)
- wherein
- R1 is Halogen or sulfonate,
- X is Fluorine atom (F),
- Y is CH2, CHD, or CD2, and
- D stands for Deuterium,
- comprising the step:
- Purification of compound of formula (I) by distillation through at least one solid phase extraction (SPE) cartridge containing a stationary phase selected from the group comprising a C8 to C30 alkyl chain, more preferably a C8 to C20 alkyl chain, even more preferably a C15 to C20 alkyl chain, most preferred a C18 alkyl chain.
4 more elements
A method for obtaining purified compounds of formula (I)
- wherein
- R1 is Halogen or sulfonate,
- X is Fluorine atom (F),
- Y is CH2, CHD, or CD2, and
- D stands for Deuterium,
- comprising the steps:
- Fluorination of compound of formula (II) with Fluorine atom (F) containing moiety for obtaining a compound of formula (I)
- wherein compound of formula (II) is
- wherein
- R1 is a leaving group selected from the group of Halogen or sulfonate,
- R2 is a leaving group selected from the group of Halogen or sulfonate,
- Y is CH2, CHD or CD2 and
- D stands for Deuterium,
- Purification of compound of formula (I) by distillation through at least one solid phase extraction (SPE) cartridge containing a stationary phase selected from the group comprising a C8 to C30 alkyl chain, more preferably a C8 to C20 alkyl chain, even more preferably a C15 to C20 alkyl chain, most preferred a C18 alkyl chain.
11 more elements
Dependencies are inferred from the claim text.