Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds

A compound of Formula I

• wherein
• R1 is hydrogen or methyl, wherein said methyl is optionally substituted with one to three fluoro;
• R2 is a 5- to 10-membered heteroaryl, having one to four heteroatoms independently selected from N, O or S, wherein at least one of the heteroatoms is N and wherein said N is optionally substituted with R4;
• and wherein said 5- to 10-membered heteroaryl is optionally substituted on carbon with one to three R3;
• R3 at each occurrence is independently selected from the group consisting of halogen, hydroxy, cyano, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C3-6Cycloalkoxy, C3-6cycloalkoxy-(CR5aR5b)m—, C3-6cycloalkyl-(CR5aR5b)n—O—, —(CR5aR5b)m—C3-6cycloalkyl or —(CR5aR5b)m-(4- to 6-membered heterocycloalkyl);
• wherein said C1-6alkyl, C1-6alkoxy or C1-6alkoxy-C1-6alkyl are each optionally substituted with one to three fluoro and wherein said C3-6cycloalkyl, C3-6cycloalkoxy and (4- to 6-membered heterocycloalkyl) moieties are optionally substituted with one to three substituents independently selected from the group consisting of fluoro, methyl, fluoromethyl, difluoromethyl or trifluoromethyl;
• R4 is hydrogen, C1-6alkyl, —(CR5aR5b)m—C3-6cycloalkyl or —(CR5aR5b)m-(4- to 6-membered heterocycloalkyl);
• wherein said C1-6alkyl, C3-6cycloalkyl and -(4- to 6-membered heterocycloalkyl) moieties are each optionally substituted with one to three substituents independently selected from fluoro, methyl, trifluoromethyl, methoxy or trifluoromethoxy;
• R5a and R5b are independently hydrogen, methyl, fluoromethyl, difluoromethyl, trifluoromethyl or methoxy;
• m at each occurrence is independently 0, 1 or 2;
• and
• n is 1, 2 or 3;
• or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.