Quantitative genomics of the relaxation response
AssigneesBeth Israel Deaconess Medical Center, Inc., The General Hospital Corporation
InventorsHerbert Benson, Gregory Fricchione, Jeffery A. Dusek, Towia Aron Libermann, Manoj Kumar Bhasin
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Abstract
Disclosed herein are assays for and methods of monitoring the relaxation response in a subject by measuring the expression level of one or more genes that are modulated in a relaxation response. Primers, probes and kits for use in the assays and methods are also provided.
Claims18
-38. (canceled)
A method of generating a relaxation gene expression profile of a subject, comprising:
- a) measuring the expression levels of one or more relaxation responsive genes in a biological sample of the subject prior to and subsequent to relaxation practice by the subject;
- b) calculating any difference in the measured expression levels of the one or more genes;
- and
- c) recording the respective calculated differences in the measured expression levels of the one or more genes;
- to thereby generate the relaxation gene expression profile of the subject.
A method of determining effectiveness of relaxation practice by a subject, comprising:
- a) generating a relaxation gene expression profile of the subject in response to relaxation practice by the subject;
- and
- b) comparing the relaxation gene expression profile generated to a standard relaxation gene expression profile indicative of a complete relaxation response;
- wherein the similarity of the relaxation gene expression profile generated for the subject to the standard gene expression profile indicates effectiveness of the relaxation practice by the subject.
A microarray for high throughput detection of gene expression levels in a biological sample comprising probes for one or more relaxation-responsive genes.
Dependencies are inferred from the claim text.