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AssigneePublic University Corporation Yokohama City University
InventorsShoichi SHIROTAKE, Atsushi YOSHIDA, Shumpei YOKOTA, Itaru ENDO
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Disclosed are cyanoacrylate polymer particles which comprise an amino acid(s) and have an average particle diameter of less than 1000 nm. The amino acid-containing particles according to the present invention can kill cancer cells by inducing apoptosis-like cell death. The particles have an especially high affinity for cell lines derived from lymphomas such as T-cell lymphoma and B-cell lymphoma. The particles can also exhibit an antiproliferative effect against some kinds of pancreatic cancer-derived cell lines. Therefore, the particles according to the present invention are useful for prevention and/or treatment of cancers.
Cyanoacrylate polymer particles which comprise an amino acid(s) and have an average particle diameter of less than 1000 nm, said particles being prepared by anionically polymerizing cyanoacrylate monomers in water in the presence of said monomers, a saccharide(s) and/or polysorbate(s), and an amino acid(s).
Dependencies are inferred from the claim text.