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US 2014/0227361 A1Published application
Cross-linked hyaluronic acid and collagen and uses thereof
AssigneeAllergan, Inc.
InventorsJacqueline A. Schroeder, Gregory S. Dapper, Kenneth C. Olson
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Abstract
The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.
Claims22
A process for preparing an injectable composition useful for correcting mammary hypoplasia, the process comprising:
- (1) contacting hyaluronic acid (HA) with a cross-linker to allow cross-linking of the HA by the cross-linker, thereby forming a first composition comprising a crosslinked HA;
- (2) contacting the crosslinked HA with collagen to form a second composition comprising a collagen layer crosslinked to and surrounding a crosslinked HA core;
- (3) homogenizing the second composition to form an injectable composition, the composition being injectable under normal manual pressure though a 25 gauge needle, thereby preparing the injectable composition useful for correcting the mammary hypoplasia.
An injectable composition useful for correcting mammary hypoplasia in a patient, the composition made by the process of:
- (1) contacting hyaluronic acid (HA) with a cross-linker to allow cross-linking of the HA by the cross-linker, thereby forming a first composition comprising a crosslinked HA;
- (2) contacting the crosslinked HA with collagen to form a second composition comprising a collagen layer crosslinked to and surrounding a crosslinked HA core;
- and
- (3) homogenizing the second composition to form an injectable composition, thereby preparing the injectable composition useful for correcting the mammary hypoplasia.
1 more element
Dependencies are inferred from the claim text.