Methods of Predicting and Treating Adverse Cardiac Events
OwnerMohan Rajapurkar, Suhas Lele +1inventors
InventorsMohan Rajapurkar, Suhas Lele, Sudhir Shah
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Abstract
The invention provides methods for treatment of acute coronary syndrome and prediction of adverse cardiac events on the basis of elevations of catalytic iron in biological fluid of a human subject. An embodiment of the invention provides a method for early detection of acute coronary syndrome (ACS) in a human subject at the time of presentation of the chest pain. The method includes analyzing a test sample of the biological fluid for amount of catalytic iron and detecting acute coronary syndrome in the human subject.
Claims12
A method of treating an acute coronary syndrome in a human, comprising the step of administering an iron chelator to a human suspected of having an acute coronary syndrome, wherein an adverse cardiac event is reduced in the human suspected of having the acute coronary syndrome following administration of the iron chelator.
A method of predicting an adverse cardiac event in a human suspected of having an adverse cardiac event, comprising the step of measuring catalytic iron in a first biological fluid sample obtained from the human suspected of having an adverse cardiac event, whereby an increase in catalytic iron in the first biological sample compared to catalytic iron in a control sample predicts that the human is having the adverse cardiac event.
Dependencies are inferred from the claim text.