Carbamoylpyridone derivatives
AssigneeConcert Pharmaceuticals, Inc.
InventorAdam Morgan
Life of this patent
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Abstract
This invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an HIV integrase inhibitor.
Claims27
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- each of X1, X2, X3, X4a and X4b is independently selected from hydrogen and deuterium;
- each of Y1, Y2a, Y2b, Y3, Y4a, Y4b, Y5a, Y5b and Y6 is independently selected from hydrogen and deuterium;
- R is selected from —CD3 and —CH3;
- and
- when R is CH3, at least one X or one Y is deuterium.
The compound of any one of the preceding claims, wherein each of X4a and X4b is hydrogen.
The compound of any one of the preceding claims, wherein each of Y2a and Y2b is hydrogen.
The compound of any one of the preceding claims, wherein each of Y4a and Y4b is hydrogen.
The compound of any one of the preceding claims, wherein each of Y5a and Y5b is hydrogen.
The compound of any one of the preceding claims, wherein R is —CH3.
The compound of any one of the preceding claims, wherein Y1 is hydrogen.
The compound of any one of the preceding claims, wherein any atom not designated as deuterium in any of the embodiments set forth above is present at its natural isotopic abundance.
A pharmaceutical composition comprising a compound of any one of the preceding claims or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.