Small humanin-like peptides
AssigneeThe Regents of the University of California
InventorsPinchas COHEN, Laura J. Cobb
Life of this patent
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Abstract
Novel peptides referred to as small humanin-like peptides (SHLPs) are provided herein along with nucleic acids encoding SHLPs and probes that selectively bind SHLPs. SHLPs have wide-ranging activity, including neuroprotective activity, anticancer activity, and cell survival activity. Also provided herein are therapeutic methods comprising administering an effective amount of an SHLP to a subject in need of treatment.
Claims14
A small humanin-like peptide (SHLP) comprising an amino acid sequence of SEQ ID NO:13 (SHLP6:
- MLDQDIPMVQPLLKVRLFND), or a variant thereof having at least 50% sequence identity to SEQ ID NO:13 , wherein the variant has at least one therapeutic activity exhibited by SEQ ID NO:13.
2-7. (canceled)
A small humanin-like peptide (SHLP) comprising an amino acid sequence of SEQ ID NO:13 (SHLP6:
- MLDQDIPMVQPLLKVRLFND), or a variant thereof having at least 65% sequence identity to an amino acid sequence of SEQ ID NO:13.
12-16. (canceled)
A pharmaceutical composition comprising (i) a small humanin-like peptide (SHLP) comprising an amino acid sequence of SEQ ID NO:13 (SHLP6:
- MLDQDIPMVQPLLKVRLFND), or a variant thereof having at least 65% identity to SEQ ID NO:13;
- and (ii) at least one pharmaceutically acceptable excipient.
A method of treating cancer in a patient, comprising administering, to a patient in need of treatment for cancer, an effective amount of a small humanin-like peptide (SHLP) having an amino acid sequence of SEQ ID NO:13 (MLDQDIPMVQPLLKVRLFND), or a variant thereof having at least 65% identity to SEQ ID NO:13.
(canceled)
An isolated polynucleotide encoding a small humanin-like peptide (SHLP) or a variant thereof, the SHLP or variant thereof comprising an amino acid sequence having at least 65% identity to an amino acid sequence of SEQ ID NO:13 (SHLP6:
- MLDQDIPMVQPLLKVRLFND).
23-24. (canceled)
Dependencies are inferred from the claim text.