Capcna peptide therapeutics for cancer
OwnerRobert J. HICKEY, Linda H. MALKASinventors
Life of this patent
Estimating the term…
Abstract
Administration of compositions comprising cell-permeable caPCNA-derived peptides and their variants reduces the proliferation of cancer cells and also augments cytotoxic effects of chemotherapeutics. The compositions are effective in cells harboring mutations in DNA repair proteins.
Claims26
A method of inducing cell death in a cancer cell or a pre-malignant cell, the method comprising administering a therapeutically effective amount of a composition comprising a caPCNA peptide molecule, wherein the caPCNA peptide molecule comprises an amino acid sequence selected from LGIPEQEY (SEQ ID NO:
- 1), LAIPEQEY (SEQ ID NO:
- 2), LGIAEQEY (SEQ ID NO:
- 3), LGIPAQEY (SEQ ID NO:
- 4), LGIPEAEY (SEQ ID NO:
- 5), LGIPEQAY (SEQ ID NO:
- 6), LGIAEAEY (SEQ ID NO:
- 7), LGIPEAAY (SEQ ID NO:
- 8), LGIAEQAY (SEQ ID NO:
- 9), and LGIAEAAY (SEQ ID NO:
- 10), wherein the cell has a mutation in a DNA repair protein.
A method of reducing cellular proliferation of a cancer cell or a pre-malignant cell of an individual, the method comprising administering a therapeutically effective amount of a composition comprising a caPCNA peptide molecule, wherein the caPCNA peptide molecule comprises an amino acid sequence selected from LGIPEQEY (SEQ ID NO:
- 1), LAIPEQEY (SEQ ID NO:
- 2), LGIAEQEY (SEQ ID NO:
- 3), LGIPAQEY (SEQ ID NO:
- 4), LGIPEAEY (SEQ ID NO:
- 5), LGIPEQAY (SEQ ID NO:
- 6), LGIAEAEY (SEQ ID NO:
- 7), LGIPEAAY (SEQ ID NO:
- 8), LGIAEQAY (SEQ ID NO:
- 9), and LGIAEAAY (SEQ ID NO:
- 10), wherein the individual has one or more mutations in a DNA repair protein.
(canceled)
A method of reducing the effective dose of a chemotherapeutic agent required to treat cancer, the method comprising administering a caPCNA peptide and a chemotherapeutic agent to an individual diagnosed with a cancer associated with one or more mutations in a DNA repair protein.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.