Systems and methods for increasing convective clearance of undesired particles in a microfluidic device

A method for filtering a first liquid containing an analyte to provide a filtered liquid containing less analyte than the first liquid, the method comprising the steps of:

• introducing the first liquid into an inlet of one or more First Channels, each First Channel having a height in the range of about 50 microns to about 500 microns, a width in the range of about 50 microns to about 900 microns, and a length in the range of about 3 centimeters to about 20 centimeters;
• introducing infusate into at least one Second Channel complementary to the one or more First Channels in a direction perpendicular to the direction of fluid flow in the one or more First Channels, such that at least some of the infusate flows from the at least one Second Channel through a first membrane and into the one or more First Channels;
• introducing waste-collecting fluid into at least one Third Channel complementary to the one or more First Channels such that at least some of the analyte of the first liquid is transported through a second membrane into the at least one Third Channel;
• and
• collecting the filtered solution from an outlet of one or more of the First Channels.