Constructing a differential diagnosis and disease ranking in a list of differential diagnosis

A non-transitory computer readable storage medium having instructions stored thereon that, when executed by a processing device, cause the processing device to execute operations comprising:

• receiving, by the processing device, one or more symptoms of a patient;
• determining a set of diseases having at least one clinical feature that overlaps with the one or more symptoms of the patient;
• determining, for each disease of the set of diseases, a prevalence ratio for the disease, the prevalence ratio comprising a ratio of a prevalence for the disease to a cumulative prevalence of the set of diseases;
• determining, by the processing device, for each disease of the set of diseases, a disease relative probability score for the disease in view of the prevalence ratio for the disease;
• determining a ranking of the diseases in the set of diseases in view of the disease relative probability scores;
• and
• outputting the ranking of the diseases.

A system comprising:

• a data store;
• and
• a processing device coupled to the data store, the processing device to:
• receive one or more symptoms of a patient,
• determine a set of diseases having at least one clinical feature that overlaps with the one or more symptoms of the patient,
• determine, for each disease of the set of diseases, a prevalence ratio for the disease, the prevalence ratio comprising a ratio of a prevalence for the disease to a cumulative prevalence of the set of diseases,
• determine, for each disease of the set of diseases, a disease relative probability score for the disease in view of the prevalence ratio for the disease, determining a ranking of the diseases in the set of diseases in view of the disease relative probability scores, and
• output the ranking of the diseases.