Systems and methods for identifying the relationships between a plurality of genes
AssigneeThe Translational Genomics Research Institute
InventorsSeungchan Kim, Sungwon Jung
Life of this patent
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Abstract
The present invention relates to a method and system for the evaluation of differential dependencies of a set of discrete random variables between two conditions. In some embodiments, the system and method compares two conditions by evaluating the probability distributions of the likely dependency networks from random variables.
Claims14
A computer implemented method of statistical testing for identifying or evaluating relationships between a plurality of genes, the method comprising:
- receiving a target gene set containing a plurality of genes across a plurality of conditions;
- evaluating each gene as a discrete random variable;
- identifying a plurality of likely dependency network structures for the plurality of genes for each condition;
- computing a probability distribution of the likely dependency network structures for each condition;
- computing overall differential dependency relationships between genes in a target gene set across the plurality of conditions by calculating a difference between each probability distribution of likely dependency network structures among the plurality of conditions;
- and
- identifying a plurality of biological functions and pathways that show genetic relationships across the plurality of conditions using the overall differential dependency relationships.
A system comprising:
- a processor;
- and a non-transitory computer-readable storage medium storing instructions which, when executed on the processor, perform a method comprising:
- receiving a target gene set containing a plurality of genes across a plurality of conditions;
- evaluating each gene as a discrete random variable;
- identifying a plurality of likely dependency network structures for the plurality of genes for each condition;
- computing a probability distribution of the likely dependency network structures for each condition;
- computing overall differential dependency relationships between genes in a target gene set across the plurality of conditions by calculating a difference between each probability distribution of the likely dependency network structures among the plurality of conditions;
- and
- identifying a plurality of biological functions and pathways that show genetic relationships across the conditions using the overall differential dependency relationships.
A method of statistical testing for identifying or evaluating relationships between a plurality of genes, the method comprising:
- obtaining a target gene set containing a plurality of genes across a plurality of conditions;
- evaluating each gene as a discrete random variable;
- identifying a plurality of likely dependency network structures for the plurality of genes for each condition;
- determining a probability distribution of the likely dependency network structures for each condition;
- determining an overall differential dependency relationships between genes in a target gene set across the plurality of conditions by calculating a difference between each probability distribution of the likely dependency network structures among the plurality of conditions;
- and
- identifying a plurality of biological functions and pathways that show genetic relationships across the plurality of conditions using the overall differential dependency relationships.
Dependencies are inferred from the claim text.