Methods and systems for treating heart instability
AssigneeThe Regents of the University of California
InventorSanjiv Narayan
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Abstract
Systems and methods define an index of risk for cardiac disease by detecting cellular derangements that may lead to cardiomyopathy, heart rhythm disorders or ischemic heart disease. The markers include fluctuations or abnormal rate-behavior of electrical, mechanical or other measurable biosignals. The invention operates in modes that can be applied to prevent atrial fibrillation or the risk for ventricular arrhythmias. Alternative embodiments are applied to tissue outside the heart such as skeletal muscle, smooth muscle, the central nervous system, the respiratory system, the urogenital system and the gastrointestinal system.
Claims21
An apparatus associated with treatment of heart rhythm disorders, the apparatus comprising:
- one or more sensors configured to detect one or more signals from a beating human heart over a plurality of time segments;
- a calculation unit configured to calculate one or a combination of signal changes in at least one of signal shape, duration of signal components, signal amplitude and signal characteristics among a first time segment and a second time segment of the plurality of time segments, wherein at least a portion of the second time segment differs from at least a portion of the first time segment in at least one of rate and regularity induced in the beating human heart;
- and
- a therapy unit configured to modify at least one of tissue structure and function based at least in part on the signal changes determined by the calculation unit.
An apparatus to assess a risk associated with a heart rhythm disorder comprising:
- at least one sensor;
- an analytic engine comprising:
- a module configured to measure a signal received via the at least one sensor from a beating human heart;
- a module configured to calculate a change in the signal among at least a first time segment and a second time segment in response to a change in at least one of rate and regularity induced in the beating human heart;
- and
- a module configured to generate a risk score for the heart rhythm disorder determined based at least in part on the change in the signal.
An apparatus associated with treatment of heart rhythm disorders comprising:
- one or more sensors configured to detect one or more signals from a beating human heart over a plurality of time periods;
- a calculation unit configured to calculate one or a combination of signal changes in at least one of signal shape, duration of signal components, signal amplitude and signal characteristics among a first time period and a second time period of the plurality of time periods, wherein at least a portion of the first time period and at least a portion of the second time period differ by a change induced in at least one of rate and regularity in the beating human heart;
- and
- an assignment unit configured to assign a risk score for a heart rhythm disorder based at least in part on the signal changes calculated by the calculation unit.
Dependencies are inferred from the claim text.