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US 2014/0194677 A1Published application
Estrus synchronization preparations and effective cidr-less protocols
OwnerJennifer Yoakum, Hal Wittinventors
Life of this patent
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Abstract
An injectable preparation of estrogenic and progestrogenic hormonal compounds in an anhydrous excipient injected to synchronize estrus in non-menstruating placental female animals, and a five to nine day protocol to apply the unique preparation to achieve estrus synchronization.
Claims18
An injectable composition for promoting CIDR-less estrus synchronization in a cycling female cow, comprising:
- (a) a steroidal estrogenic compound in an amount effective to induce estrus in a mature, cycling female cow;
- (b) a steroidal progestogen compound in an amount effective to preserve a corpus luteum intact of the cow for a period of at least five days after injection;
- and
- (c) an anhydrous excipient;
- wherein the composition is formulated for intramuscular injection.
2 more elements
A method for improving estrus synchronization or fertilization rates in a cycling, female cow, the method comprising:
- (a) administering on Day Zero to a cycling, female cow by intramuscular injection a first steroidal hormone composition comprising an estrogenic compound, a progestogen compound, and an anhydrous excipient in an amount effective to induce estrus in the cow, wherein Day Zero is at least 45 days postpartum;
- (b) administering on Day X to the cow a second composition comprising prostaglandin, or a biologically functional equivalent thereto, in an amount effective to initiate estrus, wherein Day X is from 5 to 8 days after Day Zero;
- and
- (c) administering on Day Y to the cow a third composition comprising an estrogenic compound in an amount effective to force ovulation, wherein Day Y is from 12 to 36 hours after administration of the second composition;
- wherein the cow does not comprise a controlled intravaginal hormone release device.
2 more elements
A method for improving estrus synchronization or fertilization rates in a virgin heifer, the method comprising:
- (a) administering on Day Zero to a virgin heifer by intramuscular injection a first steroidal hormone composition comprising an estrogenic compound, a progestogen compound, and an anhydrous excipient in an amount effective to induce estrus in the heifer;
- (b) administering on Day X to the heifer a second composition comprising prostaglandin, or a biologically functional equivalent thereto, in an amount effective to initiate estrus, wherein Day X is from 5 to 8 days after Day Zero;
- (c) administering on Day Y to the heifer a third composition comprising an estrogenic compound in an amount effective to force ovulation, wherein administration occurs not less than 12 hours after administration of the second composition;
- and
- (d) inseminating the heifer on Day Z, wherein insemination occurs not less than 12 hours after administration of the third composition;
- wherein the heifer does not comprise a controlled intravaginal hormone release device.
3 more elements
Dependencies are inferred from the claim text.