US 2014/0194620 A1 · 18F-LABELED PRECURSOR OF PET RADIOACTIVE MEDICAL SUPPLIES, AND PREPARATION METHOD THEREOF

Abstract

The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.

Claims11

Dependent claims

A precursor comprising a leaving group of a tetravalent organic salt, represented by the following Chemical Formula 1:

wherein, in Chemical Formula 1,
R1 is a part excluding a —X—CH2—18F part from an 18F-labeled radiotracer and represents a C1-C1000 hydrocarbon group in which a carbon in the main chain of the C1-C1000 hydrocarbon group may be non-replaced or replaced by an oxygen, a nitrogen, a sulfur, a phosphorus or combinations thereof and a hydrogen in the main chain may be non-replaced or replaced by a halogen,
X represents an oxygen, a sulfur or —C(O)—, and
the leaving group represents a non-substituted or a substituted C2-C50 tetravalent ammonium salt.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

14/117,271Filed 11 May 2012

Priority

KR 10-2011-004539013 May 2011

Published

10 Jul 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C07J 43/003
Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton: not condensed
A61K 51/04
Characterised by the carrier , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus: organic compounds
A61K 51/0406
Lipids, e.g. triglycerides; Polycationic carriers: amines, polyamines, e.g. spermine, spermidine, amino acids, guanidines
A61K 51/0493
Organic compounds: steroids, e.g. cholesterol, testosterone

18f-labeled precursor of pet radioactive medical supplies, and preparation method thereof

Life of this patent

18f-labeled precursor of pet radioactive medical supplies, and preparation method thereof

Life of this patent

Abstract

Claims11