US 2014/0194615 A1 · METHOD FOR THE PREPARATION OF 2-[4-[(METHYLAMINO)CARBONYL]-1-H-PYRAZOL-1-YL]ADENOSINE MONOHYDRATE

Abstract

A method for the preparation of 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of formula I by reaction of 2-(4-methoxycarbonylpyrazol-1-yl) adenosine of formula III with a solution of methylamine in a non-aqueous solvent, optionally in combination with another inert solvent, to produce anhydrous 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine, which is converted to 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yljadenosine monohydrate of formula I by addition of water.

Claims7

Dependent claims

A method for the preparation of 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of formula I

comprising the steps of:
a) reacting 2-(4-methoxycarbonylpyrazol-1-yl)adenosine of formula III
with methylamine in a non-aqueous solvent to produce anhydrous 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine,
b) adding water to the product of step a) to produce of 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of formula I.

1 more element

Dependencies are inferred from the claim text.

Method for the preparation of 2-[4-[(methylamino)carbonyl]-1-h-pyrazol-1-yl]adenosine monohydrate

Life of this patent

Method for the preparation of 2-[4-[(methylamino)carbonyl]-1-h-pyrazol-1-yl]adenosine monohydrate

Life of this patent

Abstract

Claims7