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US 2014/0194600 A1Published application
Use of anti-factor xi antibodies for prevention of thrombus formation
AssigneeProthix B.V.
InventorErik HACK
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Abstract
The present invention relates to binding molecules such as antibodies that specifically bind plasma coagulation factor XI and that inhibit factor XI activation and/or activity. The factor XI-binding molecules of the invention may used in methods for preventing or treating diseases, disorders and/or conditions that are mediated by factor XI activation and/or wherein inhibition of factor XI has a beneficial effect.
Claims13
An antibody or a factor XI-binding fragment thereof that binds factor XI at or near the active site located in the light chain region of activated factor XI and inhibits factor XI activity,
- wherein, when administered to a subject in an effective amount, said antibody or fragment treats or attenuates a disease, disorder or condition for which inhibition of factor XI has a beneficial effect.
Dependencies are inferred from the claim text.