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AssigneeYeda Research and Development Co. Ltd.
InventorsAlexander Gad, Dora Lis
Estimating the term…
The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between retention time and the log of the molecular weight. The molecular weight markers also optimally demonstrate biological activity similar to glatiramer acetate or corresponding copolymers and can be used for treating or preventing various immune diseases. In addition, the subject invention provides pharmaceutical compositions for the treatment of immune diseases comprising a polypeptide having an identified molecular weight and an amino acid composition corresponding to glatiramer acetate or a terpolymer.
A polypeptide for determining the molecular weight of a copolymer, said polypeptide having an identified molecular weight and an amino acid composition corresponding to said copolymer, wherein the identified molecular weight is between about 2,000 daltons and about 40,000 daltons.
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A plurality of polypeptides for determining the molecular weight of a copolymer on a molecular weight sizing column, which comprises two to about ten polypeptides, each polypeptide having an identified molecular weight and an amino acid composition corresponding to said copolymer and wherein an approximately linear relationship exists between the retention time of said polypeptides on said column and the log of the molecular weight of said polypeptides.
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A polypeptide for calibrating a molecular weight discrimination system for measuring the molecular weight of a copolymer said polypeptide having an identified molecular weight and a composition corresponding to said copolymer.
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Dependencies are inferred from the claim text.