Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
AssigneeUnited Therapeutics Corporation
InventorsRoger Andrew Jeffs, David Zaccardelli
Life of this patent
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Abstract
Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.
Claims14
-23. (canceled)
A method of reducing occurrence of a bacterial infection in a human in need of an active pharmaceutical ingredient (API) other than epoprostenol, comprising diluting a starting solution of the API with a buffer comprising glycine and having a pH of greater than 10 to provide a final solution of the API with a pH of greater than 10 and administering the final solution to the human in need thereof.
Dependencies are inferred from the claim text.