Synthesis, methods of using, and compositions of cycloalkylmethylamines
AssigneeReviva Pharmaceuticals, Inc.
InventorsLaxminarayan BHAT, Seema Rani Bhat
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Abstract
The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.
Claims20
A cycloalkylmethylamine derivative of structural Formula (IV):
- or a pharmaceutically acceptable salt thereof, wherein:
- n is 1;
- SP is a spacer selected from the group consisting of propylene, methylpropylene, and butylene;
- X is O, S, or NH;
- R2 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl;
- R4 is hydrogen, alkyl, or substituted alkyl;
- R5 is hydrogen, alkyl, halogen, hydroxyl, or alkoxy;
- R6 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl;
- and
- R7 is hydrogen, alkyl, halogen, hydroxyl, or alkoxy;
- wherein substituted means that one or more hydrogen atoms of the chemical moiety are each independently replaced with halogen, alkyl, alkoxy, or amino.
A cycloalkylmethylamine derivative of Compound 54a,
A cycloalkylmethylamine derivative of structural Formula (IV):
- or a pharmaceutically acceptable salt thereof, wherein:
- n is 1;
- SP is a direct bond;
- X is O, S, or NH;
- R2 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl;
- R4 is hydrogen, alkyl, or substituted alkyl;
- R5 is hydrogen, alkyl, halogen, hydroxyl, or alkoxy;
- R6 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl;
- and
- R7 is hydrogen, alkyl, halogen, hydroxyl, or alkoxy;
- wherein substituted means that one or more hydrogen atoms of the chemical moiety are each independently replaced with halogen, alkyl, alkoxy, or amino.
Dependencies are inferred from the claim text.