Diagnosis and treatment methods for entry of gastrointestinal contents into respiratory tract
AssigneeAradigm Corporation
InventorIgor Gonda
Life of this patent
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Abstract
A method of diagnosing in a subject for the purpose of determining if the subject's gastrointestinal contents has entered the subject's respiratory tract. The qualitative analysis can be also expanded into quantitative analysis, enabling the estimation of either the concentration, or the amount, or both, of the gastrointestinal contents that entered the respiratory tract. The invention also provides methods of treatment based on the identification of aspiration using the methods of the invention.
Claims27
A method of treating a subject suffering from entry of gastrointestinal contents into the respiratory tract, comprising:
- orally administering to a subject a diagnostic formulation comprising an agent that is not absorbed from the gastrointestinal tract of a mammal but is absorbed from the respiratory tract of a mammal;
- allowing the diagnostic formulation to remain in the subject over a period of time during which the subject would be expected to aspirate the formulation from the gastrointestinal tract into the respiratory tract;
- accessing a body fluid from the subject, wherein the body fluid is urine, blood or a blood product;
- analyzing the body fluid to detect the level of the agent in the body fluid;
- determining that the fluid contains a level of the agent indicative of aspiration of gastrointestinal contents into the respiratory tract, and providing an intervention to prevent or reduce such aspirations in the subject.
A method of treating a subject suffering from entry of gastrointestinal contents into the respiratory tract, comprising:
- orally administering to a subject a diagnostic formulation comprising a cromolyn salt;
- allowing the diagnostic formulation to remain in the subject over a period of time during which the subject would be expected to aspirate the formulation from the gastrointestinal tract into the respiratory tract;
- accessing a body fluid from the subject, wherein the body fluid is urine, blood or a blood product;
- analyzing the body fluid to detect the level of cromolyn salt in the body fluid;
- determining that the fluid contains a level of cromolyn salt indicative of aspiration of gastrointestinal contents into the respiratory tract, and
- providing an intervention to prevent or reduce such aspirations in the subject.
A dipstick device for the detection of an agent indicative of aspiration of gastrointestinal contents into the respiratory tract of a subject, comprising:
- a substrate comprised of paper and a first reagent that reacts with the agent;
- and
- a second reagent that enables the reaction of the first reagent to form a dye with the agent that is of a different color than the color either the first or the second reagent.
A dipstick device for the detection of an agent indicative of aspiration of gastrointestinal contents into the respiratory tract of a subject, comprising, comprising:
- a substrate comprised of paper and a reagent that reacts with the agent to form a compound with a visually detectable color.
A dipstick device for the detection of an agent indicative of aspiration of gastrointestinal contents into the respiratory tract of a subject, comprising:
- a substrate comprised of paper and a first reagent that reacts with the agent;
- and
- a second reagent that enables the reaction of the first reagent to form a compound with a visually detectable color.
Dependencies are inferred from the claim text.